Creating the strategic learning environment at City University London

Purpose: This paper describes the creation of a new approach to the implementation of educational technologies at a UK Higher Education Institution. Driven by changes in technology, an evaluation of the virtual learning environment (VLE) provided the opportunity to reassess the application of technology to the curriculum. However, such an evaluation and subsequent implementation is not about technology but a social process of negotiation and stakeholder engagement. The narrative of the evaluation is explored to offer lessons to other institutions. Design/methodology/approach: The paper takes a story telling approach as this enables greater emotional engagement with the reader as well as the description of the social and organisational aspects of such a VLE evaluation. This approach enables the difficulty of change in complex organisations, such as a University, to be addressed more fully. Findings: Key lessons from the evaluation of the VLE and resulting creation of the strategic learning environment (SLE) are drawn which can be of use to other institutions. The main finding is the fact that such evaluations and implementation of educational technologies are not about technical factors but about opportunities and threats presented by such technologies to the educational experience. These findings also inform future development of the SLE at the institution. Originality/value: This paper will be of interest to institutions that are undertaking evaluation exercises of their educational technology provision as well as those that are implementing new technologies or considering large scale organisational change

Flexible Learning Spaces Evaluation Report

City University, London is tackling the challenge of ensuring the learning spaces provided are able to meet the anticipated increase in technology usage and prevalent pedagogies. There is no longer a standard classroom design that will achieve this goal and therefore it is imperative to pilot and explore a variety of flexible learning spaces. This report feeds back on an evaluation of two flexible learning space approaches piloted in the autumn term of 2012 as alternatives to traditional computer rooms laid out in rows with the lecturer positioned at the front. These approaches are: pop-up computers on circular tables in AG24A; and laptop lockers enabling staff to borrow laptops to use with students on node chairs in AG24B. Each of these approaches also supported the use of students’ own devices in learning spaces. These methods were evaluated using surveys, interviews and an open house forum. The report shares the findings and recommendations from this evaluation and future plans for learning spaces

A case study of secondary school leaders' perceptions of attendance policies and procedures used to increase attendance

Field of study: Educational leadership and policy analysis.Dr. Carole A. Edmonds, Dissertation Supervisor.Includes vita."May 2018."Nationwide, pressures from outside influences such as politicians and educational policy makers are placing schools in precarious situations to make drastic changes in attendance policies to meet state accountability standards. The researcher used interviews and a focus group with school leaders, and archival data to find common themes which were then viewed through the conceptual underpinning of accountability. This case study adds to the field of education a deeper understanding of school leaders' perspectives on the impact attendance accountability standards have on the overall effectiveness of school improvement. The findings suggest: the new proportional attendance policy is detrimental to a school leaders' ability to focus on other school improvement practices while creating negative unintended consequences for schools and students; incentives and punitive consequences have short-term success while decaying school-family relationships; and district-wide and community awareness programs seemed to have the greatest impact on long term attendance improvement. Based on these findings, the following three practices should be implemented by districts: Systematic monitoring of attendance data, the use of low cost incentives and simple rewards, and the implementation of district-wide engagement and education of family and community awareness programs.Includes bibliographical references (pages 135-145)

The Future of Clinical Trials of Myopia Control

In the field of myopia control, effective optical or pharmaceutical therapies are now available to patients in many markets. This creates challenges for the conduct of placebo-controlled, randomised clinical trials, including ethics, recruitment, retention, selective loss of faster progressors and non-protocol treatments: 1. Ethics: It is valid to question whether withholding treatment in control subjects is ethical. 2. Recruitment: Availability of treatments is making recruitment into clinical trials more difficult. 3. Retention: If masking is not possible, parents may immediately withdraw their child if randomised to no treatment. 4. Selective loss: Withdrawal of fast progressors in the control group leading to a control group biased towards low progression. 5. Non-protocol treatment: Parents may access other myopia treatments in addition to those within the trial. We propose that future trials may adopt one of the following designs: A Non-inferiority trials using an approved drug or device as the control. The choice will depend on whether a regulatory agency has approved the drug or device. B Short conventional efficacy trials where data are subsequently entered into a model created from previous clinical trials, which allows robust prediction of long-term treatment efficacy from the initial efficacy. C Virtual control group trials based on data relating to axial elongation, myopia progression or both, accounting for subject\u27s age and race. D Short-term control data from a cohort, for example, 1 year or less, and applying an appropriate, proportional annual reduction in axial elongation to that population and extrapolating to subsequent years. E Time-to- treatment- failure trials using survival analysis; once a treated or control subject progresses or elongates by a given amount, they exit the study and can be offered treatment. In summary, the future development of new treatments in myopia control will be hampered if significant changes are not made to the design of clinical trials in this area

The Risks and Benefits of Myopia Control

The prevalence of myopia is increasing around the world, stimulating interest in 3 methods to slow its progression. The primary justification for slowing myopia progression is to 4 reduce the risk of vision loss through sight-threatening ocular pathology in later life. The paper 5 analyzes whether the potential benefits of slowing myopia progression by one diopter justify the 6 potential risks associated with treatments

Schizophrenia and the progression of emotional expression in relation to others

Gaining an improved understanding of people diagnosed with schizophrenia has the potential to influence priorities for therapy. Psychosis is commonly understood through the perspective of the medical model. However, the experience of social context surrounding psychosis is not well understood. In this research project we used a phenomenological methodology with a longitudinal design to interview 7 participants across a 12-month period to understand the social experiences surrounding psychosis. Eleven themes were explicated and divided into two phases of the illness experience: (a) transition into emotional shutdown included the experiences of not being acknowledged, relational confusion, not being expressive, detachment, reliving the past, and having no sense of direction; and (b) recovery from emotional shutdown included the experiences of being acknowledged, expression, resolution, independence, and a sense of direction. The experiential themes provide clinicians with new insights to better assess vulnerability, and have the potential to inform goals for therapy

Multiplicative slices, relativistic Toda and shifted quantum affine algebras

We introduce the shifted quantum affine algebras. They map homomorphically into the quantized $K$-theoretic Coulomb branches of $3d\ {\mathcal N}=4$ SUSY quiver gauge theories. In type $A$, they are endowed with a coproduct, and they act on the equivariant $K$-theory of parabolic Laumon spaces. In type $A_1$, they are closely related to the open relativistic quantum Toda lattice of type $A$.Comment: 125 pages. v2: references updated; in section 11 the third local Lax matrix is introduced. v3: references updated. v4=v5: 131 pages, minor corrections, table of contents added, Conjecture 10.25 is now replaced by Theorem 10.25 (whose proof is based on the shuffle approach and is presented in a new Appendix). v6: Final version as published, references updated, footnote 4 adde

In situ delivery of nanoparticles formulated with micron-sized crystals protects from murine melanoma.

INTRODUCTION Intratumoral injections of novel therapeutics can activate tumor antigen-specific T cells for locoregional tumor control and may even induce durable systemic protection (against distant metastases) via recirculating T cells. Here we explored the possibility of a universal immunotherapy that promotes T-cell responses in situ and beyond, upon intratumoral injection of nanoparticles formulated with micron-sized crystals. METHODS Cucumber mosaic virus-like particles containing a tetanus toxin peptide (CuMVTT) were formulated with microcrystalline tyrosine (MCT) adjuvant and injected directly in B16F10 melanoma tumors. To further enhance immunogenicity, we loaded the nanoparticles with a TLR7/8 ligand and incorporated a universal tetanus toxin T-helper cell peptide. We assessed therapeutic efficacy and induction of local and systemic immune responses, including RNA sequencing, providing broad insight into the tumor microenvironment and correlates of protection. RESULTS MCT crystals were successfully decorated with CuMVTT nanoparticles. This 'immune-enhancer' formed immunogenic depots in injected tumors, enhanced polyfunctional CD8+ and CD4+ T cells, and inhibited B16F10 tumor growth locally and systemically. Local inflammation and immune responses were associated with upregulation of genes involved in complement activation and collagen formation. CONCLUSIONS Our new immune-enhancer turned immunologically cold tumors into hot ones and inhibited local and distant tumor growth. This type of immunotherapy does not require the identification of (patient-individual) relevant tumor antigens. It is well tolerated, non-infectious, and affordable, and can readily be upscaled for future clinical testing and broad application in melanoma and likely other solid tumors

Manifest SO(N) invariance and S-matrices of three-dimensional N=2,4,8 SYM

An on-shell formalism for the computation of S-matrices of SYM theories in three spacetime dimensions is presented. The framework is a generalization of the spinor-helicity formalism in four dimensions. The formalism is applied to establish the manifest SO(N) covariance of the on-shell superalgebra relevant to N =2,4 and 8 SYM theories in d=3. The results are then used to argue for the SO(N) invariance of the S-matrices of these theories: a claim which is proved explicitly for the four-particle scattering amplitudes. Recursion relations relating tree amplitudes of three-dimensional SYM theories are shown to follow from their four-dimensional counterparts. The results for the four-particle amplitudes are verified by tree-level perturbative computations and a unitarity based construction of the integrand corresponding to the leading perturbative correction is also presented for the N=8 theory. For N=8 SYM, the manifest SO(8) symmetry is used to develop a map between the color-ordered amplitudes of the SYM and superconformal Chern-Simons theories, providing a direct connection between on-shell observables of D2 and M2-brane theories.Comment: 28 page

On All-loop Integrands of Scattering Amplitudes in Planar N=4 SYM

We study the relationship between the momentum twistor MHV vertex expansion of planar amplitudes in N=4 super-Yang-Mills and the all-loop generalization of the BCFW recursion relations. We demonstrate explicitly in several examples that the MHV vertex expressions for tree-level amplitudes and loop integrands satisfy the recursion relations. Furthermore, we introduce a rewriting of the MHV expansion in terms of sums over non-crossing partitions and show that this cyclically invariant formula satisfies the recursion relations for all numbers of legs and all loop orders.Comment: 34 pages, 17 figures; v2: Minor improvements to exposition and discussion, updated references, typos fixe